The liver is the largest organ in the body, located in the upper right portion of abdomen. It is one of the most vital organs which regulates various functions and supports the normal functioning of other organs in the body, as well. Painkillers used for arthritis are analgesics (paracetamol) and non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen). Learn about risks and side-effects. Nociceptive pain. Nociceptive pain is caused by damage to body tissue. If the pain is mild, such as a headache or a sprained ankle, commonly used over-the-counter painkillers are effective. The dizzying range of “targeted” pain-relief options in pharmacies can make your head hurt. Painkillers (sometimes called analgesics) are drugs that help to reduce pain, and are commonly used by people with arthritis to ease their pain until it gets better or during flare-ups. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Mushtaq on ibuprofen 800 mg dosage chart: Advil (ibuprofen) 800 mg is a high dose especially taken everyday can cause ulcer, damage kidneys, bleeding etc. For the first time in over 10 years I have gone 5 days without taking any paracetamol, I hope not to take any painkillers ever again unless absolutely necessary. For pain such as backpain or headaches, simple painkillers such as paracetamol and anti-inflammatory agents work best but can have potential side effects, so you need to weigh up the pros and cons. There is no absolute cure for the treatment of headache. There are however many effective treatments which can treat a headache and prevent them. Pain medicines are also called analgesics. Each kind of pain medicine has benefits and risks. Some types of pain respond better to one kind of medicine than to another kind.